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Acute SIV infection is associated with altered liver metabolism. Changes in the expression of 84 genes associated with steatotic liver disease were profiled using the <t>RT2</t> PCR array for fatty liver disease using RNA extracted from 3 SIV-infected (SIV+) and 3 SIV-naïve (SIV−) macaques with liver samples available at the 2-week time point. ( A ) The 3 genes that were different ( p < 0.10) between the SIV+ and SIV− macaques (PPARA, ABCA1, and GSK3B). ( B ) The 3 genes with the greatest fold-change in an alcoholic liver disease model in macaques are also depicted (PPARGC1A, IGFBP1, and FASN) .
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Acute SIV infection is associated with altered liver metabolism. Changes in the expression of 84 genes associated with steatotic liver disease were profiled using the <t>RT2</t> PCR array for fatty liver disease using RNA extracted from 3 SIV-infected (SIV+) and 3 SIV-naïve (SIV−) macaques with liver samples available at the 2-week time point. ( A ) The 3 genes that were different ( p < 0.10) between the SIV+ and SIV− macaques (PPARA, ABCA1, and GSK3B). ( B ) The 3 genes with the greatest fold-change in an alcoholic liver disease model in macaques are also depicted (PPARGC1A, IGFBP1, and FASN) .
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Acute SIV infection is associated with altered liver metabolism. Changes in the expression of 84 genes associated with steatotic liver disease were profiled using the RT2 PCR array for fatty liver disease using RNA extracted from 3 SIV-infected (SIV+) and 3 SIV-naïve (SIV−) macaques with liver samples available at the 2-week time point. ( A ) The 3 genes that were different ( p < 0.10) between the SIV+ and SIV− macaques (PPARA, ABCA1, and GSK3B). ( B ) The 3 genes with the greatest fold-change in an alcoholic liver disease model in macaques are also depicted (PPARGC1A, IGFBP1, and FASN) .

Journal: Viruses

Article Title: SIV Infection Is Associated with Transient Acute-Phase Steatosis in Hepatocytes In Vivo

doi: 10.3390/v16020296

Figure Lengend Snippet: Acute SIV infection is associated with altered liver metabolism. Changes in the expression of 84 genes associated with steatotic liver disease were profiled using the RT2 PCR array for fatty liver disease using RNA extracted from 3 SIV-infected (SIV+) and 3 SIV-naïve (SIV−) macaques with liver samples available at the 2-week time point. ( A ) The 3 genes that were different ( p < 0.10) between the SIV+ and SIV− macaques (PPARA, ABCA1, and GSK3B). ( B ) The 3 genes with the greatest fold-change in an alcoholic liver disease model in macaques are also depicted (PPARGC1A, IGFBP1, and FASN) .

Article Snippet: Gene expression was analyzed using the RT2 Profiler PCR Array Data Analysis Template 2024 (Qiagen) via the 2 −∆∆Ct method.

Techniques: Infection, Expressing